123311-56-8

Basic information

• Product Name: Carbonic acid (S)-cyano-p-tolyl-methyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS NO: 123311-56-8
• Molecular Weight: 329.439
• Mol File: 123311-56-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbonic acid (S)-cyano-p-tolyl-methyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonic acid (S)-cyano-p-tolyl-methyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester(123311-56-8)
• EPA Substance Registry System: Carbonic acid (S)-cyano-p-tolyl-methyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester(123311-56-8)

Safety Data

• Hazardous Substances Data: 123311-56-8(Hazardous Substances Data)

Upstream product

• 14602-86-9 (1R,2S,5R)-menthyl chloroformate 
• 10017-04-6 2-hydroxy-2-p-tolylacetonitrile 

Relevant articles and documents

The Cyclic Dipeptide cyclo as a Catalyst for Asymmetric Addition of Hydrogen Cyanide to Aldehydes

cyclo (cyclo, 1) catalyzes the addition of hydrogen cyanide to benzaldehyde in toluene at -20 deg C to afford (R)-mandelonitrile with enantiomeric excess of 97 percent in high yield. cyclo gives (S)-mandelonitrile. cyclo (1) exhibits a broad substrate specificity, and a variety of aldehydes (3a-r) such as m-methoxybenzaldehyde (3c), 6-methoxy-2-naphthaldehyde (3k), and isobutyraldehyde (3o) similarly afforded the corresponding cyanohydrins with high enantiopurities (97 percent ee for 3c, 93 percent ee for 3k, 71 percent ee for 3o). (R)-Mandelonitrile thus obtained was successfully converted to various chiral synthons such as mandelic acid (7), methyl mandelate (8), and 2-amino-1-phenylethanol (9) without any racemization.