Cas 123316-63-2,3'-(isoprenyl)-2',4-dihydroxy-4',6'-dimethoxychalcone

123316-63-2

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Basic information

Product Name: 3'-(isoprenyl)-2',4-dihydroxy-4',6'-dimethoxychalcone
Synonyms: 3'-(isoprenyl)-2',4-dihydroxy-4',6'-dimethoxychalcone
CAS NO:123316-63-2
Molecular Formula:
Molecular Weight: 368.43
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 3'-(isoprenyl)-2',4-dihydroxy-4',6'-dimethoxychalcone(CAS DataBase Reference)
NIST Chemistry Reference: 3'-(isoprenyl)-2',4-dihydroxy-4',6'-dimethoxychalcone(123316-63-2)
EPA Substance Registry System: 3'-(isoprenyl)-2',4-dihydroxy-4',6'-dimethoxychalcone(123316-63-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 123316-63-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 123316-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,3,1 and 6 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123316-63:
(8*1)+(7*2)+(6*3)+(5*3)+(4*1)+(3*6)+(2*6)+(1*3)=92
92 % 10 = 2
So 123316-63-2 is a valid CAS Registry Number.

123316-63-2Upstream product

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123316-63-2Relevant academic research and scientific papers

Natural and non-natural prenylated chalcones: Synthesis, cytotoxicity and anti-oxidative activity

Vogel, Susanne,Ohmayer, Susanne,Brunner, Gabi,Heilmann, Joerg

, p. 4286 - 4293 (2008/12/20)

A general strategy for the synthesis of 3′-prenylated chalcones was established and a series of prenylated hydroxychalcones, including the hop (Humulus lupulus L.) secondary metabolites xanthohumol (1), desmethylxanthohumol (2), xanthogalenol (3), and 4-methylxanthohumol (4) were synthesized. The influence of the A-ring hydroxylation pattern on the cytotoxic activity of the prenylated chalcones was investigated in a HeLa cell line and revealed that non-natural prenylated chalcones, like 2′,3,4′,5-tetrahydroxy-6′-methoxy-3′-prenylchalcone (9, IC50 3.2 ± 0.4 μM) as well as the phase 1 metabolite of xanthohumol (1), 3-hydroxyxanthohumol (8, IC50 2.5 ± 0.5 μM), were more active in comparison to 1 (IC50 9.4 ± 1.4 μM). A comparison of the cytotoxic activity of xanthohumol (1) and 3-hydroxyxanthohumol (8) with the non-prenylated analogs helichrysetin (12, IC50 5.2 ± 0.8) and 3-hydroxyhelichrysetin (13, IC50 14.8 ± 2.1) showed that the prenyl side chain at C-3′ has an influence on the cytotoxicity against HeLa cells only for the dihydroxylated derivative. This offers interesting synthetic possibilities for the development of more potent compounds. The ORAC activity of the synthesized compounds was also investigated and revealed the highest activity for compounds 12, 4′-methylxanthohumol (4), and desmethylxanthohumol (2), with 4.4 ± 0.6, 3.8 ± 0.4, and 3.8 ± 0.5 Trolox equivalents, respectively.

Syntheses of natural 4,4'-dihydroxy-2',6'-dimethoxy- and 4,2'-dihydroxy-4',6'-dimethoxy-3'-(γ,γ-dimethylallyl)-chalcones

Jain, A. C.,Sinha, S. P.

, p. 317 - 320 (2007/10/02)

The natural chalocone 6 has been synthesised from 6-O-methylphloroacetophenone (1) by ethoxymethylation, methylation, condensation with 4-ethoxymethoxybenzaldehyde (4) and finally deethoxymethylation with 4percent methanol

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