1233188-16-3

Upstream product

• 110-89-4 piperidine 
• 109-77-3 malononitrile 
• 1761-61-1 5-bromosalicyclaldehyde 

Relevant academic research and scientific papers

A novel, facile, rapid, solvent free protocol for the one pot green synthesis of chromeno[2,3-d]pyrimidines using reusable nano ZnAl2O4 - A NOSE approach and photophysical studies

The current protocol resulted in the preparation of an eco-friendly, highly stable, reusable nano ZnAl2O4 and for the first time this was used as an excellent catalyst for the pseudo four component synthesis of a library of fluorescent chromeno[2,3-d]pyrimidine derivatives. This novel protocol involved the grinding of salicylaldehydes, malononitrile and secondary amines in the presence of a catalytic amount of nano ZnAl2O4 at room temperature which was an extremely simple, facile, cost effective, solvent free protocol and also required just two minutes to achieve the products with excellent yields. The synthesized chromeno[2,3-d]pyrimidine derivatives showed significant absorption and emission properties and large Stoke's shift values due to their characteristic feature of an excited state intramolecular proton transfer (ESIPT) mechanism. Nano ZnAl2O4 exhibited better catalytic activity than that of the bulk due to its larger surface area of 63 m2 g-1, and was recycled 5 times without loss of activity.

Efficient One-Pot Synthesis of Quinazoline and Benzopyrano[2,3-d]pyrimidine Derivatives Catalyzed by N-Bromosulfonamides

N,N,N',N'-tetrabromobenzene-1,3-disulfonamide and poly(N,N’-dibromo-N-ethyl-benzene-1,3-disulfonamide) were used as efficient catalysts for one-pot synthesis of new quinazoline derivatives from various aldehydes, 2-amino-benzophenone, and ammonium acetate

Heteropolyacid@creatin-halloysite clay: an environmentally friendly, reusable and heterogeneous catalyst for the synthesis of benzopyranopyrimidines

A novel hybrid catalyst has been designed and synthesized based on the incorporation of heteropolyacid into creatin-functionalized halloysite clay. The catalyst was characterized by using SEM/EDS, FTIR, XRD, BET, ICP-AES, TGA and DTGA, and successfully applied for promoting the synthesis of two series of benzopyranopyrimidines under ultrasonic irradiation in aqueous media. The results established the efficiency of this protocol in terms of product yield, reaction time and the eco-friendly nature of the process. Moreover, immobilization of heteropolyacid on creatin-functionalized halloysite circumvents heteropolyacid leaching and rendered the catalyst highly reusable.

Sodium formate-catalyzed one-pot synthesis of benzopyranopyrimidines and 4-thio-substituted 4H-chromenes via multicomponent reaction at room temperature

A simple, straightforward and highly efficient multicomponent one-pot synthesis of a series of pharmaceutically interesting benzopyranopyrimidine and 4H-chromene derivatives has been developed on the basis of low-cost and environment-friendly sodium forma

Catalyst-free access to pseudo multi-component synthesis of benzopyranopyrimidines

A catalyst-free multi-component reaction of salicylaldehyde, malononitrile and secondary amine leads to the formation of benzopyranopyrimidines with intense fluorescence emission behavior is described. The method is simple, eco-friendly, economic, operable under mild conditions, having short reaction time, high yields and easy work-up procedure which suggests broad applicability of the protocol.

Mild preparation of chromeno[2,3-d]pyrimidines catalyzed by Bronsted acidic ionic liquids under solvent-free and ambient conditions

Bronsted acidic ionic liquids, namely 2-pyrrolidonium hydrogensulfate, N-methyl-2-pyrrolidonium hydrogensulfate, N-methyl-2- pyrrolidonium dihydrogenphosphate, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogensulfate, triphenyl(propyl-3-sulfonyl)phosp

Aminopropyl coated on magnetic Fe3O4 and SBA-15 nanoparticles catalyzed mild preparation of chromeno[2,3-d]pyrimidines under ambient and solvent-free conditions

3-Aminopropyltriethoxysilane coated on magnetic Fe3O4 nanoparticles [APTES-MNPs] and 3-aminopropyltriethoxysilane coated on SBA-15 [APTES-(SBA-15)] catalyzed efficiently the one-pot pseudo four-component reaction of salicylaldehydes,

ZrOCl2?8H2O as an efficient catalyst for the pseudo four-component synthesis of benzopyranopyrimidines

An efficient and environmentally benign protocol for the pseudo four-component synthesis of benzopyranopyrimidines via condensation of salicylic aldehydes, malononitrile and various amines catalyzed by ZrOCl2?8H2O as an inexpensive and eco-friendly catalyst with high catalytic activity under solvent-free conditions is reported. This protocol provides a new and improved method for obtaining benzopyranopyrimidines in terms of good yields, simple experimental procedure and short reaction time.

An eco-safe approach to benzopyranopyrimidines and 4H-chromenes in ionic liquid at room temperature

An environmentally benign, ionic liquid promoted multicomponent protocol to benzopyrano(2,3-d)pyrimidines and 4H-chromenes has been developed at room temperature. Results of the reaction depend on the nature of the nucleophile used in the reaction. Second

An efficient one-pot and solvent-free synthesis of chromeno[2,3-d] pyrimidine derivatives: Microwave assisted reaction

An efficient synthesis of some new chromeno[2,3-d]pyrimidine derivatives has been described by a solvent-free, multi-component reaction in fairly high yields. The Japan Institute of Heterocyclic Chemistry.