1233211-51-2Relevant academic research and scientific papers
Facile double-lithiation of a transient urea: Vicarious ortho -metalation of aniline derivatives
Houlden, Chris E.,Lloyd-Jones, Guy C.,Booker-Milburn, Kevin I.
, p. 3090 - 3092 (2010)
A convenient one-pot method for the conversion of phenylisocyanate into ortho-functionalized aniline derivatives has been developed. The reaction proceeds via the selective ortho-metalation of a transient labile urea, which can be considered as a synthetic equivalent of 2-lithio-phenylisocyanate, a highly improbable intermediate.
