1233216-87-9Relevant academic research and scientific papers
Synthesis and evaluation of amino-modified α-galcer analogues
Trappeniers, Matthias,Chofor, Rene,Aspeslagh, Sandrine,Li, Yali,Linclau, Bruno,Zajonc, Dirk M.,Elewaut, Dirk,Calenbergh, Serge Van
, p. 2928 - 2931 (2010)
α-GalCer analogues featuring a phytoceramide 3- and 4-amino group have been synthesized. A Mitsunobu reaction involving phthalimide was employed for the introduction of the amino groups at the 3- and 4-positions of suitable phytosphingosine-derived precursors. The influence of these modifications on the interaction with the T-cell receptor of NKT cells was investigated, as well as the capacity of the amino-modified analogues to induce a cytokine response after in vivo administration.
