1233220-76-2Relevant academic research and scientific papers
Diketene as an alternative substrate for a new Biginelli-like multicomponent reaction: one-pot synthesis of 5-carboxamide substituted 3,4-dihydropyrimidine-2(1H)ones
Shaabani, Ahmad,Seyyedhamzeh, Mozhdeh,Maleki, Ali,Hajishaabanha, Fatemeh
, p. 4040 - 4042 (2010)
5-Carboxamide substituted 3,4-dihydropyrimidine-2(1H)one derivatives were synthesized in a simple and efficient method from the one-pot four-component reactions of an aliphatic or aromatic amine, diketene, an aromatic aldehyde and urea or thiourea in the presence of p-toluenesulfonic acid as a catalyst under mild reaction conditions at ambient temperature.
