1233224-71-9

Basic information

• Product Name: 9-(4-aminomethylphenylmethyl)adenine
• Synonyms: 9-(4-aminomethylphenylmethyl)adenine
• CAS NO: 1233224-71-9
• Molecular Weight: 254.294
• Mol File: 1233224-71-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 9-(4-aminomethylphenylmethyl)adenine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-aminomethylphenylmethyl)adenine(1233224-71-9)
• EPA Substance Registry System: 9-(4-aminomethylphenylmethyl)adenine(1233224-71-9)

Safety Data

• Hazardous Substances Data: 1233224-71-9(Hazardous Substances Data)

Upstream product

• 1233224-70-8 9-[4-(N-benzyloxycarbonylaminomethyl)phenylmethyl]adenine 
• 1020415-08-0 (4-((((benzyloxy)carbonyl)amino)methyl)phenyl)methanol 
• 39895-56-2 4-hydroxymethyl-benzylamine 
• 56-91-7 p-aminomethylbenzoic acid 

Relevant articles and documents

Progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein- mediated multidrug efflux: Design, synthesis, characterization and biological evaluation

Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). The syntheses of 19 progesterone-adenine hybrids are described. Their abilities to inhibit P-glycoprotein-mediated daunorubicin efflux in K562/R7 human leukemic cells overexpressing P-glycoprotein were evaluated versus progesterone. The hybrid with a hexamethylene linker chain showed the best inhibitory potency. The efficiency of these progesterone-adenine hybrids depends on two main factors: (i) the nature of the linker and (ii) its attachment point on the steroid skeleton.