1233334-63-8Relevant academic research and scientific papers
Click-Dimerized Cinchona Alkaloids
Boratyński, Przemys?aw J.,Kowalczyk, Rafa?
, p. 8029 - 8034 (2016)
A series of Cinchona alkaloid-derived dimers were obtained in high yields in copper-catalyzed 1,3-dipolar click cycloaddition using bis(TMS)butadiyne and other bivalent alkynes. The products with bitriazole linkers were effective ligands for asymmetric copper-catalyzed Michael addition. It was shown that the presence of such linker was responsible for effective chirality transfer.
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents
Kumar, Atul,Sharma, Siddharth,Tripathi, Vishwa Deepak,Maurya, Ram Awatar,Srivastava, Swayam Prakash,Bhatia, Gitika,Tamrakar,Srivastava, Arvind Kumar
experimental part, p. 4138 - 4148 (2010/08/06)
A series of 2,4-disubstituted polyhydroquinoline were synthesized and evaluated for their in vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized compounds have exhibited promising in vivo antihyperglycemic in SLM, STZ-S, and db/db mice model along with significant lipid and TG modulating activity. All these compounds were evaluated in various in vitro models of diabetes to know the possible mechanism of their antihyperglycemic action. Interestingly, compounds 3a-r (diaryl substitution) have exhibited promising protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity whereas, compounds 5a-d (acid substituted) have shown significant glycogen phosphorylase activity.
