1233334-76-3

Upstream product

• 16943-75-2 4-(4-fluorophenyl)-2-oxo-3-butenoic acid 
• 126-81-8 dimedone 
• 1233334-71-8 ethyl-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-2-carboxylate 

Relevant academic research and scientific papers

TiO2-SiO2 nanocomposite-promoted efficient cyclocondensation reaction of arylmethylidenepyruvic acids with dimedone in aqueous media

This work focuses on the successful synthesis of 4-aryl-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acids through a condensation reaction of arylmethylidenepyruvic acids with ammonium acetate and dimedone using a catalytic amount of TiO2–SiO2 nanocomposite (15 mol%) at room temperature in aqueous media. The principal advantage of this procedure is the relatively high yields (94–98%) with short reaction times (2 hr), under mild reaction conditions and with low environmental impact.

Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents

A series of 2,4-disubstituted polyhydroquinoline were synthesized and evaluated for their in vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized compounds have exhibited promising in vivo antihyperglycemic in SLM, STZ-S, and db/db mice model along with significant lipid and TG modulating activity. All these compounds were evaluated in various in vitro models of diabetes to know the possible mechanism of their antihyperglycemic action. Interestingly, compounds 3a-r (diaryl substitution) have exhibited promising protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity whereas, compounds 5a-d (acid substituted) have shown significant glycogen phosphorylase activity.