1233344-36-9Relevant academic research and scientific papers
Identification of new non-carboxylic acid containing inhibitors of aldose reductase
Maccari, Rosanna,Ciurleo, Rosella,Giglio, Marco,Cappiello, Mario,Moschini, Roberta,Corso, Antonella Del,Mura, Umberto,Ottanà, Rosaria
experimental part, p. 4049 - 4055 (2010/08/06)
Non-carboxylic acid containing bioisosteres of (5-arylidene-2,4-dioxothiazolidin-3-yl)acetic acids, which are active as aldose reductase (ALR2) inhibitors, were designed by replacing the carboxylic group with the trifluoromethyl ketone moiety. The in vitr
