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1233381-55-9

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1233381-55-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1233381-55-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,3,3,8 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1233381-55:
(9*1)+(8*2)+(7*3)+(6*3)+(5*3)+(4*8)+(3*1)+(2*5)+(1*5)=129
129 % 10 = 9
So 1233381-55-9 is a valid CAS Registry Number.

1233381-55-9Downstream Products

1233381-55-9Relevant academic research and scientific papers

Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents

Belmonte-Reche, Efres,Martínez-García, Marta,Pe?alver, Pablo,Gómez-Pérez, Verónica,Lucas, Ricardo,Gamarro, Francisco,Pérez-Victoria, José María,Morales, Juan Carlos

, p. 132 - 140 (2016/05/24)

Trypanosomiasis and leishmaniasis keep being a real challenge for health and development of African countries. Existing treatments have considerable side effects and increase resistance of the parasites. We have measured antitrypanosomal and antileishmanial activity of natural phenols, tyrosol (TYR) and hydroxytyrosol (HT) and several of their esters and metabolites. We found significant IC50 values against Trypanosoma brucei for HT decanoate ester and HT dodecanoate ester (0.6 and 0.36 μM, respectively). This represents a large increase in activity with respect to HT (79 and 132 fold, respectively). Moreover, both compounds displayed a high selectivity index against MRC-5, a non-tumoral human cell line (118 and 106, respectively). Then, we synthesized a focused library of compounds to explore structure-activity. We found the ether and thiourea analogs of HT decanoate ester and HT dodecanoate ester also showed IC50 values against T. brucei in the low micromolar range. In conclusion, the di-ortho phenolic ring and medium size alkyl chain are essential for activity whereas the nature of the chemical bond among them seems less important.

Surface-active properties of lipophilic antioxidants tyrosol and hydroxytyrosol fatty acid esters: A potential explanation for the nonlinear hypothesis of the antioxidant activity in oil-in-water emulsions

Lucas, Ricardo,Comelles, Francisco,Alcantara, David,Maldonado, Olivia S.,Curcuroze, Melanie,Parra, Jose L.,Morales, Juan C.

experimental part, p. 8021 - 8026 (2011/09/20)

Our group has recently observed a nonlinear tendency in antioxidant capacity of different hydroxytyrosol fatty acid esters in fish oil-in-water emulsions, where a maximum of antioxidant efficiency appeared for hydroxytyrosol octanoate. These results appea

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