1233382-63-2Relevant academic research and scientific papers
Enantioselective total synthesis of the selective PI3 kinase inhibitor liphagal
Alvarez-Manzaneda, Enrique,Chahboun, Rachid,Alvarez, Esteban,Cano, Ma Jose,Haidour, Ali,Alvarez-Manzaneda, Ramon
supporting information; experimental part, p. 4450 - 4453 (2010/12/24)
The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K α isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic liphagane skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.
