1233390-20-9

Basic information

• Product Name: (+)-6-cyano-3-(N-methylamino)-1,2,3,4-tetrahydrocarbazole hydrochloride
• CAS NO: 1233390-20-9
• Molecular Weight: 261.754
• Mol File: 1233390-20-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-6-cyano-3-(N-methylamino)-1,2,3,4-tetrahydrocarbazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-6-cyano-3-(N-methylamino)-1,2,3,4-tetrahydrocarbazole hydrochloride(1233390-20-9)
• EPA Substance Registry System: (+)-6-cyano-3-(N-methylamino)-1,2,3,4-tetrahydrocarbazole hydrochloride(1233390-20-9)

Safety Data

• Hazardous Substances Data: 1233390-20-9(Hazardous Substances Data)

Upstream product

• 147009-33-4 rac-6-cyano-3-N-methylamino-l,2,3,4-tetrahydrocarbazole 

Relevant articles and documents

METHOD FOR PREPARING AN OPTICALLY ACTIVE FROVATRIPTAN

Disclosed Process for the preparation of optically active Frovatriptan or a salt comprising of : (i) Combining the racemic 6-cyano-3-N-methylamino- 1,2,3,4- tetrahydrocarbazole of formula (I) with D-Pyroglutamic acid as the resolving agent in a Resolution solvent and crystallizing from the said mixture the diastereomeric salt of compound of formula (II) with optically pure D- Pyroglutamic acid; (ii) Separation of desired (+)-6-cyano-3-N-methylamino-l,2,3,4- tetrahydrocarbazole of the formula (III) from the diastereomeric salt (II) using simple filtration technique; (iii) Hydrolyzing compound of formula (III) with phosphoric acid to get R-(+)-6-carboxamido-3-N-methylamino-l,253,4-tetrahydrocarbazole (frovatriptan) of the formula (IV).