1233477-41-2Relevant academic research and scientific papers
Electrophilic aromatic selenylation: New OPRT inhibitors
Abdo, Mohannad,Zhang, Yong,Schramm, Vern L.,Knapp, Spencer
supporting information; experimental part, p. 2982 - 2985 (2010/11/19)
2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.
