123348-81-2Relevant academic research and scientific papers
Oxydation vanadique de la papaverine en milieu sulfurique 2,5 M et 5 M
Postaire, E.,Martinez, D.,Viel, C.,Chastagnier, M.,Hamon, M.
, p. 982 - 988 (2007/10/02)
Vanadic oxidation of papaverine 1 in 5 M sulfuric acid media shows a full oxidation into carbon dioxide and water.However, according to the experimental conditions, and in 2.5 M and 5 M sulfuric acid media, intermediates and products have been identified: papaveraldine 2, hemipinimide 4, meta-hemipinic acid 3, 6,7-dimethoxy isoquinoline 5, 1-formyl 6,7-dimethoxy isoquinoline 6, 1-acetyl 6,7-dimethoxy isoquinoline 7, 4-hydroxy 6-demethyl papaveraldine 8, 4-hydroxy 4'demethyl papaveraldine 9, 3-hydroxy 6-demethyl papaveraldine 10 and 3-hydroxy 4'-demethyl papaveraldine 11.
Identification de Nouvelles Structures Benzoyl-1 Isoquinoleiniques Obtenues par Oxydation de la Papaverine
Postaire, Eric,Viel, Claude,Martinez, Didier,Likforman, Joseph,Hamon, Michel
, p. 4064 - 4067 (2007/10/02)
Papaverine 1 was oxidized by vanadium pentoxide in 2.5 M aqueous sulfuric acid media to give four new compounds: 4-hydroxy-6-demethylpapaveraldine (3), 4-hydroxy-4'-demethylpapaveraldine (4), 3-hydroxy-6-demethylpapaveraldine (5) and 3-hydroxy-4'-demethylpapaveraldine (6).The structures were established on the basis of mass spectrometry, ultraviolet-infrared spectrometry, nuclear magnetic resonance measurements and also chemical correlation with papaveraldine 2.Keywords - papaverine; 1-benzoylisoquinoline; papaveraldine; 4-hydroxy-6-demethylpapaveraldine; 4-hydroxy-4'-demethylpapaveraldine; 3-hydroxy-6-demethylpapaveraldine; 3-hydroxy-4'-demethylpapaveraldine
