1233480-53-9Relevant academic research and scientific papers
5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-α and mTOR for the treatment of breast cancer
Zhang, Nan,Ayral-Kaloustian, Semiramis,Anderson, James T.,Nguyen, Thai,Das, Sasmita,Venkatesan, Aranapakam M.,Brooijmans, Natasja,Lucas, Judy,Yu, Ker,Hollander, Irwin,Mallon, Robert
supporting information; experimental part, p. 3526 - 3529 (2010/08/20)
A series of 5-ureidobenzofuran-3-one indoles as potent inhibitors of PI3Kα and mTOR has been developed. The best potency in cells was obtained when the urea group was extended to a 4-[2-(dimethylamino)ethyl]methylamino amidophenyl group. A 7-fluoro group
