1233488-33-9Relevant academic research and scientific papers
Synthesis and antimicrobial evaluation of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles
Manikrao,Fursule,Kunjwani,Mahajan,Sable
experimental part, p. 301 - 302 (2011/12/14)
A series of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles (6) were synthesized under microwave irradiation and also by conventional method and were characterized by IR, 1H NMR and elemental analysis. The title compounds were subje
Synthesis and biological screening of novel derivatives of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles
Manikrao, Anil M.,Fursule, Ravindra A.,Rajesh,Kunjwani, Harish K.,Sabale, Prafulla M.
experimental part, p. 1642 - 1647 (2011/03/17)
3-Mercapto-(4H)-1,2,4-triazole has been synthesized from 1-formylthiosemicarbazide. Different N-substituted β-chloropropionamides have been prepared by reacting substituted amines with β- chloropropionylchloride. Different Nsubstituted β-chloropropionamides have been condensed with 3-mercapto-(4H)-1,2,4-triazole in basic medium to obtain various 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles. The structure of the synthesized compounds are confirmed by IR, 1H NMR spectra and elemental analysis. All the compounds have been screened for their analgesic, anti-inflammatory and anxiolytic activity.
