1233641-52-5Relevant academic research and scientific papers
KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue
Yamakoshi, Hiroyuki,Kanoh, Naoki,Kudo, Chieko,Sato, Atsuko,Ueda, Kazunori,Muroi, Makoto,Kon, Shunsuke,Satake, Masanobu,Ohori, Hisatsugu,Ishioka, Chikashi,Oshima, Yoshiteru,Osada, Hiroyuki,Chiba, Natsuko,Shibata, Hiroyuki,Iwabuchi, Yoshiharu
, p. 273 - 276 (2010)
Bis(arylmethylidene)acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis(arylmethylidene)acetone, inhibits cancer cell growth. We also show that GO-Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an important role in cellular proliferation and whose expression is regulated by KSRP/FUBP2.
