123365-99-1Relevant academic research and scientific papers
Studies on Quinolizine Derivatives. XXIII. Synthesis and Reactions of Methylthioazacycl-azines
Matsuda, Yoshiro,Gotou, Hiromi,Katou, Keisuke,Matsumoto, Hiroshi
, p. 1188 - 1191 (2007/10/02)
Dimethyl 7-acyl-9-cyano-1-azacyclazine-2,3-dicarboxylates (4,6) were synthesized via 1-acyl-3-cyano-4-imino-4H-quinolizines (3,5) as key intermediates.The nucleophilic substitution of the methylthio group in antiaromatic azacyclazines (6b, 9, 13) gave the corresponding products.The reaction of 9 or 13 with methyl acetoacetate gave the fused diazacyclazines (12, 16), which are examples of a new ring system.Keywords: azacyclazine; nucleophilic substitution; fused diazacyclazine; 1H-NMR spectra; steric hindrance
