1233689-64-9 Usage
Uses
Used in Pharmaceutical Research:
3-Iodo-iMidazo[1,2-a]pyrazine is used as a key intermediate for the synthesis of biologically active molecules and pharmaceutical drugs. Its unique structure allows for further chemical reactions and modifications, making it a valuable component in the development of new medications.
Used in Chemical Research:
In the field of chemical research, 3-Iodo-iMidazo[1,2-a]pyrazine is employed as a versatile building block for the creation of various organic compounds. Its ability to undergo chemical reactions and modifications contributes to the advancement of chemical science and technology.
Used in Medicinal Research:
3-Iodo-iMidazo[1,2-a]pyrazine is utilized as a fundamental component in medicinal research, where it aids in the discovery and development of new drugs. Its structural properties make it an ideal candidate for the synthesis of compounds with potential therapeutic applications.
Used in Agrochemical Research:
In agrochemical research, 3-Iodo-iMidazo[1,2-a]pyrazine is used as a key component in the development of new agrochemicals. Its role in the synthesis of biologically active molecules contributes to the creation of innovative products for agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1233689-64-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,3,6,8 and 9 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1233689-64:
(9*1)+(8*2)+(7*3)+(6*3)+(5*6)+(4*8)+(3*9)+(2*6)+(1*4)=169
169 % 10 = 9
So 1233689-64-9 is a valid CAS Registry Number.
1233689-64-9Relevant academic research and scientific papers
From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase
Juillet, Charlotte,Ermolenko, Ludmila,Boyarskaya, Dina,Baratte, Blandine,Josselin, Béatrice,Nedev, Hristo,Bach, Stéphane,Iorga, Bogdan I.,Bignon, Jér?me,Ruchaud, Sandrine,Al-Mourabit, Ali
, p. 1197 - 1219 (2021/02/05)
Significant inhibition of Aurora B was achieved by the synthesis of simplified fragments of benzosceptrins and oroidin belonging to the marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation of kinase inhibition enabled the discovery of a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into the potent CJ2-150 (37). Here we present the synthesis of new inhibitors of Aurora B kinase, which is an important target for cancer therapy through mitosis regulation. The biologically oriented synthesis yielded several nanomolar inhibitors. The optimized compound CJ2-150 (37) showed a non-ATP competitive allosteric mode of action in a mixed-type inhibition for Aurora B kinase. Molecular docking identified a probable binding mode in the allosteric site "F"and highlighted the key interactions with the protein. We describe the improvement of the inhibitory potency and specificity of the novel scaffold as well as the characterization of the mechanism of action.
