1233868-85-3

Basic information

• Product Name: N-(2,3-dichlorophenyl)-6-nitroquinazolin-4-amine
• Synonyms: N-(2,3-dichlorophenyl)-6-nitroquinazolin-4-amine
• CAS NO: 1233868-85-3
• Molecular Formula: C₁₄H₈Cl₂N₄O₂
• Molecular Weight: 335
• Mol File: 1233868-85-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,3-dichlorophenyl)-6-nitroquinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dichlorophenyl)-6-nitroquinazolin-4-amine(1233868-85-3)
• EPA Substance Registry System: N-(2,3-dichlorophenyl)-6-nitroquinazolin-4-amine(1233868-85-3)

Safety Data

• Hazardous Substances Data: 1233868-85-3(Hazardous Substances Data)

Upstream product

• 39263-34-8 N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide 
• 608-27-5 2,3-dichloroaniline 

Relevant articles and documents

Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

A useful and rapid access to 4-anilino-6-nitroquinazolines was investigated in a multi-gram scale via microwave-accelerated condensation and Dimroth rearrangement of the starting anilines with imines obtained by reaction of anthranilonitriles with formamide dimethylacetal. A novel short and efficient route to Azixa (EPi28495, MPC-6827), a microtubule destabilizing agent and apoptosis inducer, was performed with success demonstrating that well controlled parameters offer comfortable using of microwave technology with safe and environmental benefits.