1233881-82-7Relevant articles and documents
Palladium-catalyzed intramolecular aerobic C-H amination of enamines for the synthesis of 2-trifluoromethylindoles
Wei, Feng,Shen, Xiao-Qin,Chu, Jing-Jing,Hu, Bo-Lun,Zhang, Xing-Guo
, p. 720 - 725 (2018)
A new palladium-catalyzed C-H amination of aryl enamines for the synthesis of trifluoromethylated indoles is established. The attractive features of this transformation are the use of atom-economical O2 as the oxidant and easily prepared enamines as substrates. A variety of pharmaceutically important 2-trifluoromethyl indoles can be targeted in moderate to good yields with good functional compatibility.
Synthesis of 1-substituted 2-(trifluoromethyl)indoles via a palladium-catalyzed double animation reaction
Dong, Shu-Xiang,Zhang, Xing-Guo,Liu, Qiong,Tang, Ri-Yuan,Zhong, Ping,Li, Jin-Heng
experimental part, p. 1521 - 1525 (2010/10/03)
A new, selective protocol for the synthesis of 1-substituted 2-(trifluoromethyl)indoles has been developed by palladium-catalyzed double amination reaction of 2-chloro-1-(2-halophenyl)-3,3,3-trifluoroprop-1-enes with primary amines. This route allows the formation of two C-N bonds in one pot from the reaction between 2-chloro-1-(2-halophenyl)-3,3,3-trifluoroprop-1-enes and primary amines using the Pd2(dba)3/L4/t-BuONa system. Georg Thieme Verlag Stuttgart.