123389-84-4Relevant articles and documents
10,10-dihydro-10-[(substituted-carbonyl)imino]-10-phenyl-10H-phenoxaphosphines compositions containing same and therapeutic methods of use
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, (2008/06/13)
Novel 10,10-Dihydro-10-[(substituted carbonyl)imino]-10-phenyl-10H-phenoxaphines of the formula: STR1 wherein A is selected from the group consisting of hydrogen and COOR1, where, when A is hydrogen the compound is in the form of a water soluble salt HnX, where n is an integer 1 or 2 and X is selected from the group consisting of sulfate, trefluoroacetate, bromide and chloride and R1 is selected from the group consisting of straight or branched chain alkyl(C1 -C4), alkenyl(C2 -C4), alkynyl(C2 -C4), cycloalkyl(C3 -C6), cycloalkyl(C3 -C6)methyl, benzyl, pyridylmethyl or which tetrahydro-3-furanyl; methods for using these compounds for effecting diuresis, treating hypertension and edema and lowering plasma renin activity in mammals; pharmaceutical compositions of matter containing these compounds and processes for their preparation.