123394-77-4

Upstream product

• 123394-74-1 (4S,5R,2'R)-1,5-dimethyl-4-phenyl-3-(2'-benzyloxy-3'-phenylpropanoyl)imidazolidin-2-one 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 
• 1220352-31-7 (2S,4R)-3-[(R)-2-benzyloxy-1-hydroxy-3-phenylpropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine 
• 123394-73-0 (4S,5R)-1,5-dimethyl-4-phenyl-3-benzyloxyacetylimidazolidin-2-one 
• 19810-31-2 Benzyloxyacetyl chloride 
• 173180-06-8 (R)-1-(tert-Butyl-diphenyl-silanyloxy)-3-phenyl-propan-2-ol 
• 17131-14-5 (R)-3-phenylpropane-1,2-diol 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 173180-08-0 ((R)-2-Benzyloxy-3-phenyl-propoxy)-tert-butyl-diphenyl-silane 

Downstream Products

• 173243-79-3 (S)-2-[(1R,2R)-2-((R)-2-Benzyloxy-3-phenyl-propoxycarbonyl)-1-methoxy-propyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1220352-35-1 (2R)-[(R)-2-benzyloxy-3-phenylpropyl]-3,3,3-trifluoro-2methoxy-2-phenylpropanoate 
• 173243-77-1 (2R,3R)-3-[(S)-1-((3R,4S,5S)-4-{[(2S,3S)-2-((S)-2-Dimethylamino-3-methyl-butyrylamino)-3-methyl-pentanoyl]-methyl-amino}-3-methoxy-5-methyl-heptanoyl)-pyrrolidin-2-yl]-3-methoxy-2-methyl-propionic acid (R)-2-benzyloxy-3-phenyl-propyl ester 
• 17131-14-5 (S)-(-)-3-phenyl-1,2-propanediol 
• 17131-14-5 (R)-3-phenylpropane-1,2-diol 

Relevant academic research and scientific papers

Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates

Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.

Highly diastereoselective α-hydroxylation of fox chiral auxiliary-based amide enolates with molecular oxygen

"Figure Presented" Using a trifluoromethylated oxazolidine (Fox) chiral auxiliary, the hydroxylation reaction of enolates was very efficiently performed under smooth and friendly conditions with molecular oxygen as oxidizer. This reaction occurred with an extremely high diastereoselectivlty. After cleavage, the chlral auxiliary Is efficiently recovered and highly valuable enantlopure oxygenated carboxylic acids and alcohols are released.

ENANTIOSELECTIVE SYNTHESIS OF 2-BENZYLOXY ALCOHOLS AND 1,2-DIOLS VIA ALKYLATION OF CHIRAL GLYCOLATE IMIDES. A CONVENIENT APPROACH TO OPTICALLY ACTIVE GLYCEROL DERIVATIVES

The alkylation of the chiral enolates of glycolate imides 2a and 2b proceedes in highly diastereoselective manner to give 2'-substituted products in good yield.Reductive cleavage with LiBH4 affords the corresponding 2-benzyloxyalcohols 3a-c and 11a-b which are successively converted to 1,2-diols in high optical purity.By this method (R)-1-propanoyloxy-2,3-propanediol 9 and (S)-1-tridecyloxy-2,3-propanediol 14, a glyceride extracted from sponges Plocamiidae, have been synthesized, starting from 2a and 2b, respectively.