1233940-40-3Relevant academic research and scientific papers
Decarboxylative Organocatalyzed Addition Reactions of Fluoroacetate Surrogates for the Synthesis of Fluorinated Oxindoles
Zetschok, Dominik,Heieck, Lukas,Wennemers, Helma
, p. 1753 - 1757 (2021)
Fluorinated malonic acid half thioesters (F-MAHTs) were used as thioester enolate equivalents in organocatalyzed addition reactions to isatins. The products from a range of different N-protected and nonprotected isatins were obtained under mild reaction conditions in high yields and enantioselectivities. The unique reactivity of the thioester moiety enabled diverse derivatization and allowed for the straightforward access to a fluorinated analogue of the anticancer agent (S)-YK-4-279, a therapeutically active compound against Ewing's sarcoma.
Synthesis of Isatins through Direct Oxidation of Indoles with IBX-SO3K/NaI
Bredenkamp, Angla,Mohr, Fabian,Kirsch, Stefan F.
supporting information, p. 1937 - 1943 (2015/06/30)
The direct conversion of indoles into isatins is presented. The reagent mixture NaI/IBX-SO3K, containing a sulfonylated derivative of 2-iodoxybenzoic acid, was employed to trigger this oxidative process. Moreover, the synthetic route toward IBX-SO3K and the X-ray crystal structure of the title compound are described in great detail.
Copper-catalyzed intramolecular C-H oxidation/acylation of formyl- N -arylformamides leading to indoline-2,3-diones
Tang, Bo-Xiao,Song, Ren-Jie,Wu, Cui-Yan,Liu, Yu,Zhou, Ming-Bo,Wei, Wen-Ting,Deng, Guo-Bo,Yin, Du-Lin,Li, Jin-Heng
supporting information; experimental part, p. 8900 - 8902 (2010/08/21)
A new, efficient Cu-catalyzed intramolecular C-H oxidation/acylation method has been developed for the synthesis of substituted indoline-2,3-diones (isatins). In the presence of CuCl2 and O2, a variety of formyl-N-arylformamides underwent the tandem reaction to afford the corresponding indoline-2,3-diones in moderate to good yields. It is noteworthy that the reaction serves as the first example of transition-metal-catalyzed transformation for the preparation of indoline-2,3-diones.
