1233940-87-8

Basic information

• Product Name: 5-nitro-7-((4-(phenylsulfonyl)piperazin-1-yl)methyl)quinolin-8-ol
• CAS NO: 1233940-87-8
• Molecular Weight: 428.469
• Mol File: 1233940-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-nitro-7-((4-(phenylsulfonyl)piperazin-1-yl)methyl)quinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-7-((4-(phenylsulfonyl)piperazin-1-yl)methyl)quinolin-8-ol(1233940-87-8)
• EPA Substance Registry System: 5-nitro-7-((4-(phenylsulfonyl)piperazin-1-yl)methyl)quinolin-8-ol(1233940-87-8)

Safety Data

• Hazardous Substances Data: 1233940-87-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 4008-48-4 nitroxoline 
• 14172-55-5 1-(phenylsulphonyl)piperazine 

Relevant articles and documents

Synthesis and structure-activity relationship study of 8-hydroxyquinoline- derived Mannich bases as anticancer agents

To continue our early study on the structural modifications of clioquinol, more 8-hydroxyquinoline-derived Mannich bases were synthesized and examined for growth-inhibitory effect. Taken Mannich base 1 as our lead compound, upon replacement of either sulfonyl group with methylene group or piperazine ring with ethylenediamine group resulted in an appreciable increase in potency. On the other hand, as 8-hydroxyquinoline was replaced with phenol, 3-hydroxypyridine and 1-naphthol, a dramatic decrease in activity was observed, indicating that 8-hydroxyquinoline is a crucial scaffold for activity. Further 3D-QSAR analysis on HeLa cells revealed that both steric and electronic effects contributed equally to growth inhibition. Taken together, the structure-activity relationships obtained from both in vitro data and CoMFA model warrant a valuable reference for further study.