123405-51-6

Basic information

• Product Name: 4-(4-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE
• Synonyms: 4-(4-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE;4-(4-METHYL-1H-BENZIMIDAZOL-2-YL)-BENZENAMINE;AKOS AP0119
• CAS NO: 123405-51-6
• Molecular Formula: C₁₄H₁₃N₃
• Molecular Weight: 223.27
• Mol File: 123405-51-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE(123405-51-6)
• EPA Substance Registry System: 4-(4-METHYL-1 H-BENZOIMIDAZOL-2-YL)-PHENYLAMINE(123405-51-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 123405-51-6(Hazardous Substances Data)

Upstream product

• 733753-70-3 1-nitrobenzimidazole 
• 150-13-0 4-amino-benzoic acid 
• 2687-25-4 3-methyl-1,2-benzenediamine 

Relevant articles and documents

1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl] -urea derivatives as small molecule heparanase inhibitors

A novel class of 1-[4-(1H-benzoimidazol-2-yl)-phenyl]-3-[4-(1H- benzoimidazol-2-yl)-phenyl]-ureas are described as potent inhibitors of heparanase. Among them are 1,3-bis-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea (7a) and 1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)-phenyl]-urea (7d), which displayed good heparanase inhibitory activity (IC50 0.075-0.27 μM). Compound 7a showed good efficacy in a B16 metastasis model.

Benzimidazole derivatives as modulators of IgE

This invention relates to a family of benzimidazole analogs, which are inhibitors of the IgF response to allergens. These compounds are useful in the treatment of allergy, asthma, or any diseases where IgE is pathogenic.

Benzimidazole derivatives as modulators of IgE

This invention relates to a family of diacyl benzimidazole analogs, which are inhibitors of the IgE response to allergens. These compounds are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic.