1234064-06-2Relevant academic research and scientific papers
Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes
Dumitrescu, Lidia,Huong, Doan Thi Mai,Hung, Nguyen Van,Crousse, Benoit,Bonnet-Delpon, Danièle
, p. 3213 - 3218 (2010)
Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluoromethyl howiinol A 16 exhibited similar activities on several cell lines in the micromolar range. Unlike (R) goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems.
