1234071-64-7Relevant academic research and scientific papers
Synthesis of cis-3,4-diaryl α-methylene-γ-butyrolactams via sonochemical Barbier-type reaction
Lee, Adam Shih-Yuan,Chang, Yu-Ting
, p. 3800 - 3802 (2010)
A series of cis-3,4-diaryl a-methylene-c-butyrolactams were synthesized by the addition reaction of 3-phenylallyl bromide with N-tosyl aldimine via sonochemical Barbier-type reaction condition and then followed by the in situ intramolecular amidation. The cis-3,4-diaryl α-methylene-β- butyrolactam was obtained as the sole regio-and stereoisomeric product when N-tosyl aldimine was used as the substrate whereas the monoaryl α-methylene-β-butyrolactam was also generated when N-phenyl aldimine was used.
