1234099-38-7Relevant academic research and scientific papers
Enhancing the divergent activities of betulinic acid via neoglycosylation
Goff, Randal D.,Thorson, Jon S.
, p. 461 - 464 (2009)
(Chemical Equation Presented) Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, on the basis of the appended sugar, into two distinct compound subsets.
