123419-96-5Relevant academic research and scientific papers
Mechanistic studies of a "declick" reaction
Meadows, Margaret K.,Sun, Xiaolong,Kolesnichenko, Igor V.,Hinson, Caroline M.,Johnson, Kenneth A.,Anslyn, Eric V.
, p. 8817 - 8824 (2019/10/16)
A kinetic analysis of a "declick" reaction is described. Compound 1, previously reported to couple an amine and a thiol (i.e. "click") under mild aqueous conditions to create 2, undergoes release of the unaltered coupling partners upon triggering with dit
Convenient synthesis of 5-(arylamino(alkylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-diones and 2-arylthio-4-quinolones
Tang, Jing,Huang, Xian
, p. 140 - 141 (2007/10/03)
Meldrum's acid reacted with an aryl isothiocynate and alkyl halides to afford the 5-(arylamino(alkylthio)methylene)-5-methylthio-2,2-dimethyl-1,3-dioxane-4, 6-diones and the compounds underwent thermal cyclization to give the 4-2-arylthio-4(1H)-quinolones.
Reactions of Meldrum's Acid with Isocyanates and Isothiocyanates
Augustin, Manfred,Guenther, Eckhard
, p. 1005 - 1015 (2007/10/02)
Meldrum's acid (1) reacts with isothiocyanates and LiH as base, yielding after alkylation the ketene-S,N-acetales 3, 4 and 5.Protonation of the lithium-thiolate 2 gives the thioamides 7 with tautomers 8, which can be methylated with diazomethane to 9.From
