123426-37-9Relevant articles and documents
Palladium catalyzed oxidative Suzuki coupling reaction of indolizine at the 3-position using oxygen gas as the only oxidant
Hu, Huayou,Liu, Yong,Xu, Juan,Kan, Yuhe,Wang, Chao,Ji, Min
, p. 24389 - 24393 (2014)
Stoichiometric metal oxidant applied in the functionalization of indolizine at the 3-position through C-H activation in a previous report was found to increase the cost of the synthesis and worsen the environmental pollution. In this paper, we developed a Pd(OAc)2/O2 catalytic system with or without ligands for an oxidative Suzuki coupling reaction of indolizine at the 3-position through C-H activation. As reported in the literature, some indolizines dimerized when catalyzed by palladium acetate under ligand-free conditions. However, we found that the dimerization of 2,3-unsubstituted indolizines was inhibited by the addition of ligands. Based on this finding, the arylation of these indolizines can be successfully achieved via a Pd(OAc)/O2 system using picolinic acid as a ligand. 1,2-disubstituted indolizines that do not easily dimerize can react smoothly with arylboronic acids under ligand-free conditions. Furthermore, broad group tolerance was shown in both indolizine and arylboronic acid. Finally, this method has the advantages of mild conditions, a broad array of starting materials and the use of a green oxidant. The Royal Society of Chemistry 2014.
REACTION DU FLUOROBORATE DU BENZOYL-2 DIHYDRO-1,2 ISOQUINALDONITRILE AVEC LES ESTERS α,β-ETHYLENIQUES CAS DES ESTERS ACRYLIQUE, FUMARIQUE ET MALEIQUE. COMPETITION ENTRE LES REACTIONS DE CYCLOADDITION ET .
Schmitt, Gerard,Laude, Bernard,Vebrel, Joeel,Rodier, Noeel,Theobald, Francois
, p. 113 - 124 (2007/10/02)
In all reactions studied up the present time with olefinic esters, the Reissert salts have given only the Diels-Alder adducts.By adding triethylamine to the reaction medium, we have found evidence for competing 1,3-dipolar cycloaddition and Diels-Alder re
