123433-61-4

Upstream product

• 4071-85-6 trimetylsilylketene 
• 5470-84-8 4-benzyloxybutanal 

Downstream Products

• 33606-34-7 (2-(tetrahydro-furan-2-yl)-ethanol) 
• 2434-00-6 (tetrahydro-furan-2-yl)-acetic acid 
• 123433-58-9 (Tetrahydro-furan-2-yl)-acetic acid benzyl ester 
• 126502-90-7 (3S,4S)-4-(3-Benzyloxy-propyl)-3-methyl-oxetan-2-one 
• 126502-90-7 (3R,4S)-4-(3-Benzyloxy-propyl)-3-methyl-oxetan-2-one 
• 126502-90-7 4-(3-Benzyloxy-propyl)-3-methyl-oxetan-2-one 
• 123433-56-7 4-(3-Benzyloxy-propyl)-oxetan-2-one 
• 139609-09-9 threo-4-<3-(benzyloxy)propyl>-3-(ethylhydroxymethyl)-2-oxetanone 
• 139609-09-9 erythro-4-<3-(benzyloxy)propyl>-3-(ethylhydroxymethyl)-2-oxetanone 

Relevant academic research and scientific papers

Studies of the asymmetric [2+2] cycloaddition of silylketenes and aldehydes employing Ti-TADDOL catalysts

Ti-TADDOL catalysts provide good reactivity and moderate enantioselectivity in the asymmetric [2+2] cycloaddition of silyl ketenes and aldehydes. The effects of potential bidentate chelation of benzyloxy substituted aldehydes and of the steric size of the ketene silyl group were studied.

A new approach to the preparation of 2-substituted tetrahydrofurans with alpha-syn selectivity

A strategy for selectively preparing 2-substituted tetrahydrofurans bearing α-syn side chain stereochemistry, based on intramolecular 2-oxetanone ring opening, has been demonstrated. A new approach to the preparation of 3,4-disubstituted 2-oxetanones is also presented.

SYSTHESIS AND INTRAMOLECULAR RING CLEAVAGE OF 2-OXETANONES

Intermolecular 2+2 aldehyde-ketene cycloaddition, followed by Lewis acid induced intramolecular ring opening of the 2-oxetanone product have been used to prepare tetrahydrofuran and tetrahydropyran ring systems.