1234331-27-1Relevant academic research and scientific papers
Palladium-catalyzed allylation of aryl halides with homoallyl alcohols bearing a trisubstituted double bond: Application to chirality transfer from hydroxylated carbon to benzylic one
Wakabayashi, Ryota,Fujino, Daishi,Hayashi, Sayuri,Yorimitsu, Hideki,Oshima, Koichiro
, p. 4337 - 4343 (2010)
(Figure presented) A facile route to homoallyl alcohols bearing a trisubstituted double bond has been devised. The palladium-catalyzed reactions of aryl halides with the alcohols thus synthesized result in regiospecific allyl transfer from the alcohols to aryl halides via retro-allylation, providing allylarenes having two substituents at the 1 and 2 positions of the allyl moiety. Optically active homoallyl alcohols transfer their chirality at the hydroxylated carbon to the benzylic carbon of the product.
