1234331-56-6

Basic information

• Product Name: 3-(chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline
• Synonyms: 3-(chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline
• CAS NO: 1234331-56-6
• Molecular Weight: 311.786
• Mol File: 1234331-56-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline(1234331-56-6)
• EPA Substance Registry System: 3-(chloromethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline(1234331-56-6)

Safety Data

• Hazardous Substances Data: 1234331-56-6(Hazardous Substances Data)

Upstream product

• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 

Downstream Products

• 147489-06-3 (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester 
• 147526-32-7 pitavastatin calcium salt 
• 147526-32-7 pitavastatin 
• 586966-54-3 (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester 
• 1234331-52-2 2-({[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}thio)benzo[d]thiazole 

Relevant articles and documents

Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction

An efficient and concise asymmetric synthesis of pitavastatin calcium (1) starting from commercially available (S)-epichlorohydrin is described. A convergent C1 + C6 route allowed for the assembly of the pitavastatin C7 side chain via a Wittig reaction between phosphonium salt 2 and the enantiomerically pure C6-formyl side chain 3. The 1,3-syn-diol acetal motif in 3 was established with excellent stereo control by a diastereoselective bismuth-promoted two-component hemiacetal/oxa-Michael addition reaction of (S)-α,β-unsaturated ketone 4 with acetaldehyde.