Cas 1234347-92-2,(2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

1234347-92-2

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Basic information

Product Name: (2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Synonyms: (2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
CAS NO:1234347-92-2
Molecular Formula:
Molecular Weight: 401.246
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol(CAS DataBase Reference)
NIST Chemistry Reference: (2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol(1234347-92-2)
EPA Substance Registry System: (2S,3R,4R,5S,6R)-2-(4-chloro-3-((6-chloropyridazin-3-yl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol(1234347-92-2)

Safety Data

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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
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Hazardous Substances Data: 1234347-92-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1234347-92-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,4,3,4 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1234347-92:
(9*1)+(8*2)+(7*3)+(6*4)+(5*3)+(4*4)+(3*7)+(2*9)+(1*2)=142
142 % 10 = 2
So 1234347-92-2 is a valid CAS Registry Number.

1234347-92-2Upstream product

1259020-60-4 C₂₅H₂₆Cl₂N₂O₉

1234347-92-2Downstream Products

1234347-92-2Relevant academic research and scientific papers

NOVEL C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

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Page/Page column 80-81, (2010/12/31)

A novel C-aryl glucoside compound, or a pharmaceutically acceptable salt or a prodrug thereof having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney; and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly, diabetes, are provided.

Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: Pyridazinylmethylphenyl glucoside congeners

Kim, Min Ju,Lee, Junwon,Kang, Suk Youn,Lee, Sung-Han,Son, Eun-Jung,Jung, Myung Eun,Lee, Suk Ho,Song, Kwang-Seop,Lee, MinWoo,Han, Ho-Kyun,Kim, Jeongmin,Lee, Jinhwa

supporting information; scheme or table, p. 3420 - 3425 (2010/08/07)

Novel C-aryl glucoside SGLT2 inhibitors containing pyridazine motif were designed and synthesized for biological evaluation. Among the compounds tested, pyridazine containing methylthio moiety 22l or thiadiazole ring 22ah showed the best in vitro inhibitory activities in this series (IC50 = 13.4, 11.4 nM, respectively) against SGLT2 to date. Subsequently, compound 22l exhibited reasonable urinary glucose excretion and glucosuria in normal SD rats, thereby demonstrating that this pyridazine series possesses both in vitro SGLT2 inhibition and in vivo efficacy, albeit to a lower degree.

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