1234490-75-5Relevant academic research and scientific papers
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus
McGuigan, Christopher,Madela, Karolina,Aljarah, Mohamed,Gilles, Arnaud,Brancale, Andrea,Zonta, Nicola,Chamberlain, Stanley,Vernachio, John,Hutchins, Jeff,Hall, Andrea,Ames, Brenda,Gorovits, Elena,Ganguly, Babita,Kolykhalov, Alexander,Wang, Jin,Muhammad, Jerry,Patti, Joseph M.,Henson, Geoffrey
, p. 4850 - 4854 (2010)
We herein report a novel double pro-drug approach applied to the anti-HCV agent 2′-β-C-methyl guanosine. A phosphoramidate ProTide motif and a 6-O-methoxy base pro-drug moiety are combined to generate lipophilic prodrugs of the monophosphate of the guanin
PHOSPHORAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS
-
Page/Page column 90-92, (2010/08/04)
Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
