123452-64-2Relevant academic research and scientific papers
A carbonate-forming Baeyer-Villiger monooxygenase
Hu, Youcai,Dietrich, David,Xu, Wei,Patel, Ashay,Thuss, Justin A.J.,Wang, Jingjing,Yin, Wen-Bing,Qiao, Kangjian,Houk,Vederas, John C.,Tang, Yi
, p. 552 - 554 (2014)
Despite the remarkable versatility displayed by flavin-dependent monooxygenases (FMOs) in natural product biosynthesis, one notably missing activity is the oxidative generation of carbonate functional groups. We describe a multifunctional Baeyer-Villiger monooxygenase, CcsB, which catalyzes the formation of an in-line carbonate in the macrocyclic portion of cytochalasin E. This study expands the repertoire of activities of FMOs and provides a possible synthetic strategy for transformation of ketones into carbonates.
