1234549-10-0

Basic information

• Product Name: S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-dithioaspartate
• Synonyms: S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-dithioaspartate
• CAS NO: 1234549-10-0
• Molecular Weight: 625.761
• Mol File: 1234549-10-0.mol

Chemical Properties

• CAS DataBase Reference: S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-dithioaspartate(CAS DataBase Reference)
• NIST Chemistry Reference: S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-dithioaspartate(1234549-10-0)
• EPA Substance Registry System: S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-dithioaspartate(1234549-10-0)

Safety Data

• Hazardous Substances Data: 1234549-10-0(Hazardous Substances Data)

Upstream product

• 13726-67-5 Boc-Asp-OH 
• 212555-23-2 (2,4,6-trimethoxyphenyl)methanethiol 

Downstream Products

• 1345827-44-2 S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-phenylalanyl-L-thioaspartate 
• 1345827-45-3 S,S'-bis(2,4,6-trimethoxybenzyl) N-benzyloxycarbonyl-L-phenylalanyl-L-phenylalanyl-L-thioaspartate 

Relevant articles and documents

Cyclic peptide synthesis with thioacids

(Figure Presented) C-Terminal amino acid 9-fluorenylmethylthioesters may be carried through Boc chemistry solution phase peptide synthesis sequences. After insertion of the final residue in the form of an Fmoc carbamate, treatment with piperidine releases a seco-peptide as a C-terminal thioacid that on treatment with Sanger's reagent undergoes cyclization to a cyclic peptide. Cyclic penta- and hexapeptides have been synthesized in this manner, as has a cyclic glycopeptide. Functional group compatibility with alcohols and carboxylic acids is demonstrated.