1234564-31-8

Basic information

• Product Name: (S)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoate
• Synonyms: (S)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoate
• CAS NO: 1234564-31-8
• Molecular Weight: 455.52
• Mol File: 1234564-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoate(1234564-31-8)
• EPA Substance Registry System: (S)-ethyl 3-(N-benzyl-N-((R)-1-phenylethyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoate(1234564-31-8)

Safety Data

• Hazardous Substances Data: 1234564-31-8(Hazardous Substances Data)

Upstream product

• 38235-77-7 (R)-N-benzyl-1-phenylethylamine 
• 101466-85-7 ethyl (E)-4-trifluoromethylcinnamate 

Downstream Products

• 1234564-32-9 tert-butyl (S)-2-(ethoxycarbonyl)-1-(4-(trifluoromethyl)phenyl)ethylcarbamate 

Relevant articles and documents

Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier

By employing pharmacophore-based design and the privileged fragments reassembly, a series of piperidine-/tropane-/piperazine-bridged CCR5 antagonists were designed and synthesized via an efficient convergent synthesis strategy, with focus on the optimal choice of the basic center carrier structure. Significantly, the 4-amino-4-methylpiperidine bridged 1-acyl-1,3-propanediamine compounds were identified as a new class of nanomolar CCR5 antagonists, providing an efficient approach and novel scaffolds for further development of potent CCR5 inhibitors.