1234572-18-9Relevant academic research and scientific papers
General access to chiral n -alkyl terminal aziridines via organocatalysis
Fadeyi, Olugbeminiyi O.,Schulte, Michael L.,Lindsley, Craig W.
supporting information; experimental part, p. 3276 - 3278 (2010/10/21)
(Figure Presented) A three step, one-pot protocol involving enantioselective α-chlorination of aldehydes, subsequent reductive amination with a primary amine, and SN2 displacement to afford chiral N-alkyl terminal aziridines in 40-65% yield (74-87%/step) and, in most cases, >90% ee is reported.
