1234580-83-6

Basic information

• Product Name: C₁₉H₁₃NO₂
• Synonyms: C₁₉H₁₃NO₂
• CAS NO: 1234580-83-6
• Molecular Weight: 287.318
• Mol File: 1234580-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₃NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₃NO₂(1234580-83-6)
• EPA Substance Registry System: C₁₉H₁₃NO₂(1234580-83-6)

Safety Data

• Hazardous Substances Data: 1234580-83-6(Hazardous Substances Data)

Upstream product

• 100516-88-9 6-(hydroxymethyl)quinoline 
• 63888-21-1 benzyl 3-phenyl-2-propynoate 

Downstream Products

• 1234580-68-7 6-(3-phenylprop-2-ynyl)quinoline 

Relevant articles and documents

Decarboxylative benzylations of alkynes and ketones

Benzyl esters of propiolic and β-keto acids undergo catalytic decarboxylative coupling when treated with appropriate palladium catalysts. Such decarboxylative couplings allow the benzylation of alkynes without the use of strong bases and/or organometallics. This allows the synthesis of sensitive benzylic alkynes that are prone to undergo isomerizations under basic conditions. Additionally, decarboxylation facilitates the site-specific benzylation of diketones and ketoesters under mild, base-free conditions. Ultimately, the methodology described expands our ability to cross-couple medicinally relevant heterocycles.