1234619-97-6Relevant articles and documents
A new synthesis of 2,3-Di- or 2,3,3-trisubstituted 2,3-Dihydro-4-pyridones by reaction of 3-ethoxycyclobutanones and N - P -Toluenesulfonyl imines using titanium(IV) chloride: Synthesis of (±)-bremazocine
Matsuo, Jun-Ichi,Okado, Ryohei,Ishibashi, Hiroyuki
supporting information; experimental part, p. 3266 - 3268 (2010/10/04)
(Figure Presented) N-p-Toluenesulfonyl (Ts) aldimines reacted with 3-ethoxycyclobutanones by catalysis of titanium(IV) chloride to afford 2,3-di- or 2,3,3-trisubstituted N-Ts-2,3-dihydro-4-pyridones. Synthesis of (±)-bremazocine was efficiently accomplished by using this method.