123463-81-0

Basic information

• Product Name: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid mono-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester
• CAS NO: 123463-81-0
• Molecular Weight: 452.591
• Mol File: 123463-81-0.mol

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid mono-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid mono-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester(123463-81-0)
• EPA Substance Registry System: (R)-2-(4-Methoxy-benzyl)-2-methyl-malonic acid mono-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl] ester(123463-81-0)

Safety Data

• Hazardous Substances Data: 123463-81-0(Hazardous Substances Data)

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 122778-27-2 (1R,3R,4S)-8-phenyl-p-menthan-3-yl hydrogen methylmalonate 

Relevant articles and documents

Enantioselective Construction of a Quaternary Asymmetric Carbon Center: A Versatile Synthesis of α-Alkyl α-Amino Acids

The enantioselective construction of a quaternary asymmetric carbon center was developed through reaction of the dianions derived from the chiral half esters of monosubstituted malonic acids with 2 molar equi of LDA and alkyl halides.Alkylation in the reverse sequence preferentially gave the same diastereomer.The alkylated half esters were transformed into α-alkyl α-amino acids.