123463-81-0Relevant articles and documents
Enantioselective Construction of a Quaternary Asymmetric Carbon Center: A Versatile Synthesis of α-Alkyl α-Amino Acids
Ihara, Masataka,Takahashi, Masanobu,Niitsuma, Hiroko,Taniguchi, Nobuaki,Yasui, Ken,Fukumoto, Keiichiro
, p. 5413 - 5415 (1989)
The enantioselective construction of a quaternary asymmetric carbon center was developed through reaction of the dianions derived from the chiral half esters of monosubstituted malonic acids with 2 molar equi of LDA and alkyl halides.Alkylation in the reverse sequence preferentially gave the same diastereomer.The alkylated half esters were transformed into α-alkyl α-amino acids.