123469-92-1Relevant articles and documents
Synthetic method of bepidic acid
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Paragraph 0033-0034; 0040-0041; 0047-0048, (2021/03/13)
The invention belongs to the field of medicine synthesis, and relates to a novel synthesis method of a compound bepidic acid. The preparation method comprises the following steps: (1) carrying out primary alkylation on ethyl isobutyrate and 1, 5-dibromopentane under the action of lithium diisopropylamide to generate a compound 1; (2) carrying out alkylation twice on dibenzyl malonate and the compound 1 under the action of sodium hydride to generate a compound 2; (3) removing benzyl from the compound 2 under the action of Pd/C and hydrogen to obtain a compound 3; (4) carrying out electrochemical reaction on the compound 3 in a methanol solution of methanol and ammonia to obtain a compound 4; (5) finally carrying out sodium borohydride hydrolysis and potassium hydroxide hydrolysis on the compound 4, and acidifying to obtain the final bepidic acid. The method is carried out under electrochemical conditions, is mild in conditions and high in efficiency, and is suitable for industrial production.
Synthesis method of 8-hydroxy-2, 2, 14, 14-tetramethyl pentadecanedioic acid
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Paragraph 0047-0050, (2021/09/11)
The invention provides a synthesis method for preparing 8-hydroxy-2, 2, 14, 14-tetramethyl pentadecanedioic acid, which comprises the step of carrying out addition reaction on a compound III and a compound IV to obtain a compound II. The method has the advantages of cheap and easily available raw materials and short steps, and can greatly reduce the production cost; the operation is simple, and industrial production is facilitated; and the quality of reaction products in each step is controllable, and the obtained product is high in purity and small in single impurity.
Method for synthesizing ethyl-2,2-dimethyl-7-bromoheptanoate
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Paragraph 0030; 0033-0075, (2020/09/30)
The invention discloses a method for synthesizing ethyl-2,2-dimethyl-7-bromoheptanoate. The method comprises the following steps: introducing ethyl isobutyrate and an organic alkali reagent into a continuous flow reactor through a metering pump; preparing an ethyl isobutyrate lithium salt solution through pre-cooling, mixing and reacting; continuously reacting the solution with 1,5-dibromopentanein a continuous flow reactor, completing quenching operation through a quenching post-treatment module, and finally performing post-treatment to obtain a substituted product, namely ethyl-2,2-dimethyl-7-bromoheptanoate. The method has the advantages that conditions are accurately controlled, selectivity is good, the amplified production of the product becomes possible, operation is simple, convenient and safe, yield is high, a reaction rate is high, etc.; and huge practical values are obtained in the aspects of improving production safety, improving the yield and output of ethyl-2,2-dimethyl-7-bromoheptanoate and improving production efficiency.