1234708-03-2

Upstream product

• 1234707-86-8 (4R,5S,9R,E)-((4S,5R,7S,8S)-8-(tert-butyldimethylsilyloxy)-4,7-dimethylnon-1-en-5-yl) 5-(tert-butyldimethylsilyloxy)-11-((tert-butyldimethylsilyloxy)methyl)-9-(4-methoxybenzyloxy)-4-methyldodeca-6,11-dien-2-ynoate 
• 917-54-4 methyllithium 

Relevant academic research and scientific papers

Enantioselective synthesis of a diastereomer of iriomoteolide-1a. What is the correct structure of the natural product?

(Figure Presented) An enantioselective approach to a diastereomer of iriomoteolide-1a is described. Highlighted is a SmI2-mediated intramolecular reductive cyclization approach to complex cyclic hemiketals. An acetylide-chloroformate coupling strategy is also featured. Our results show that the structures of iriomoteolide-1a-1c require careful reassessment.