1234709-86-4

Upstream product

• 360555-33-5 (R)-tert-butyl 3-(2-aminophenylcarbamoyl)piperidine-1-carboxylate 
• 95-54-5 1,2-diamino-benzene 
• 163438-09-3 (R)-1-Boc-nipecotic acid 

Downstream Products

• 1365879-82-8 4-(biphenyl-4-yl)-3-hydroxy-1-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one 
• 1365884-36-1 tert-butyl (R)-4-((R)-3-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-1-(4-bromophenyl)-4-oxobutan-2-ylcarbamate 
• 1365879-80-6 (R)-1-((R)-3-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-3-amino-4-(biphenyl-4-yl)butan-1-one 
• 1365884-39-4 tert-butyl (R)-1-(4-bromophenyl)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate 
• 1365884-40-7 tert-Butyl (R)-1-(biphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate 
• 1365879-81-7 (R)-3-amino-4-(biphenyl-4-yl)-1-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one 
• 1365885-59-1 methyl 4'-((R)-2-(tert-butoxycarbonylamino)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutyl)biphenyl-4-carboxylate 
• 1365886-28-7 4'-((R)-2-(tert-butoxycarbonylamino)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutyl)biphenyl-4-carboxylic acid 
• 1365886-58-3 tert-butyl (R)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate 
• 1365886-59-4 tert-butyl (R)-4-((R)-3-(1-(3-ethoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-yl)-1-(4-(2-methoxythiazol-4-yl)phenyl)-4-oxobutan-2-ylcarbamate 
• 1365886-61-8 tert-butyl (R)-1-(4-(cyclohexylcarbamoyl)phenyl)-4-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate 
• 1365886-60-7 (R)-3-amino-4-(4-(2-ethoxythiazol-4-yl)phenyl)-1-((R)-3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)butan-1-one trifluoroacetate 
• 1365884-37-2 tert-butyl (R)-4-((R)-3-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-1-(biphenyl-4-yl)-4-oxobutan-2-ylcarbamate 
• 1365885-82-0 tert-butyl (R)-1-(2'-chlorobiphenyl-4-yl)-4-((R)-3-(1-(3-methoxypropyl-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-4-oxobutan-2-yl)carbamate 

Relevant academic research and scientific papers

Renin inhibitors

The invention relates to compounds having the formulae: wherein the variables are as defined herein. The invention further relates to methods of making and using these compounds, and pharmaceutical compositions, kits and articles of manufacture comprise the compounds.

SEROTONIN 5-HT2B RECEPTOR INHIBITORS

Disclosed are Serotonin 5-HT2B receptor inhibitors of the formula I. Also disclosed are methods of making and methods of using these compounds