1234793-73-7Relevant academic research and scientific papers
Thiodiketopiperazines produced by the endophytic fungus epicoccum nigrum
Wang, Jia-Ming,Ding, Guang-Zhi,Fang, Lei,Dai, Jun-Gui,Yu, Shi-Shan,Wang, Ying-Hong,Chen, Xiao-Guang,Ma, Shuang-Gang,Qu, Jing,Xu, Song,Du, Dan
, p. 1240 - 1249 (2010)
Thirteen new thiodiketopiperazines, epicoccin I (1), ent-epicoccin G (2), and epicoccins J-T (3-13), together with six known diketopiperazines (14-19), have been isolated from the endophytic fungus Epicoccum nigrum. The structures of 1, 2, and 10 were confirmed by X-ray crystallography, and the absolute configurations of 2, 4, 6, and 8 were assigned using Moshers' method. Compounds 2, 6, 12, and 17 showed potent activities in vitro against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with IC50 values of 3.07, 4.16, 4.95, and 1.98 μM, respectively. None of the 19 compounds exhibited detectable cytotoxic activities toward six tumor cell lines (A549, Be-l7402, BGC-823, HCT-8, HCT-116, and A2780) in the MTT assay.
