1234793-83-9Relevant academic research and scientific papers
Efficient construction of the core framework of lysidicin A via three Claisen rearrangements including a cascade reaction
Ogura, Yusuke,Watanabe, Hidenori
scheme or table, p. 3294 - 3296 (2010/07/18)
A model compound (6) with the core skeleton of lysidicin A was synthesized as a racemate. The key step (8→7) includes three Claisen rearrangements of the triether with phloroglucinols; two of which rearranged in a cascade manner and the other was a simple rearrangement. This one-pot reaction enabled the introduction of three phloroglucinol units at the correct positions and makes the synthetic approach significantly efficient.
