123482-72-4Relevant academic research and scientific papers
Renin inhibitors based on dipeptide analogues. Incorporation of the hydroxyethylene isostere at the P2/P3 sites
Kempf,De Lara,Stein,Cohen,Egan,Plattner
, p. 371 - 374 (2007/10/02)
The synthesis of a series of renin inhibitors in which the P2 and P3 amino acids are replaced with the hydroxyethylene dipeptide isostere is reported. In vitro evaluation of the inhibitors has revealed that this isostere is an accept
